: Lipofilling

Lipofilling

Lipofilling also called "autologous fat transfer" is a technique based on the application of patient's own fat to add volume to the tissue. As solely a body's own substance is used, this procedure is comparably safe and well tolerated.

Lipofilling can be well combined with the PRP treatment resulting in a naturally beautiful appearance.

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Fast, well tolerated, 100% body's own fat

Benefits

Body’s own substances, therefore comparably safe and well tolerated
Naturally beautiful appearance
Possibility to combine autologous fat / regenerative cells with, e.g., platelet rich plasma (PRP) for stimulation of the body’s own regeneration processes¹

The ACA (autologous conditioned adipose tissue) technique allows to obtain 2 types of body own substances:

Adipose tissue (microfat) for lipofilling
Regenerative cells – SVF (stromal vascular fraction) for rejuvenation, scar revision and wound healing

Procedure

 Your physician performs liposuction from the appropriate donor site of your body (e.g., belly, waist or thigh).
Depending on your target zone, a minimum of 15 ml of adipose tissue is harvested to isolate the regenerative cells. A special system is used to perform this procedure.
 Your physician then injects these cells at the treatment site (e.g., your face) to stimulate the body’s own regeneration processes.^2–4
The injected cells harbour a range of different functions, including promoting skin rejuvenation through remodeling processes of the tissue and supporting the blood supply to the treated area.^4,6,10,11  In combination with lipofilling, regenerative cells can support volume improvement to create longer-lasting results.

Applications of autologous fat / regenerative cells

Skin rejuvenation^2-6
Lipofilling^5,7-10
Scar revision^10-11
Wound Healing^{5,12, 13}

Disclaimer:
For risks and adverse events associated with the use of the product consult your medical practitioner and the instructions for use.

References:
¹ Loibl M et al. The effect of leukocyte-reduced platelet-rich plasma on the proliferation of autologous adipose-tissue derived mesenchymal stem cells. Clin Hemorheol Microcirc. 2016;61(4):599-61
²Park BS et al. Adipose-derived stem cells and their secretory fators as a promising therapy for skin aging. Dermatol Surg. 2008 Oct;34(10):1323-6
³ Tonnard P et al. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg. 2013 Oct;132(4):1017-26
⁴ Charles-de-Sá L et al. Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells. Plast Reconstr Surg. 2015 Apr;135(4):999-1009
⁵ Stevens HP. ACA-Technik: „stromal vascular fraction“, „platelet-rich plasma“ und Mikrofett zur körpereigenen Regeneration und Hautverjüngung J Ästhet Chir 1-7, 2018
⁶ Surowiecka A, et al. Stromal vascular fraction and emulsified fat as regenerative tools in rejuvenation of the lower eyelid area. Dermatol Ther. 2021 May;34(3):e14937
⁷ Prantl L, Brix E, Kempa S, Felthaus O, Eigenberger A, Brébant V, Anker A, Strauss C. Facial Rejuvenation with Concentrated Lipograft-A 12 Month Follow-Up Study. Cells. 2021 Mar 8;10(3):594
⁸ Chang Q et al. Quantitative volumetric analysis of progressive hemifacial atrophy corrected using stromal vascular fraction-supplemented autologous fat grafts. Dermatol Surg. 2013 Oct;39(10):1465-73
⁹ Yoshimura K et al. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg. 2008 Jan;32(1):48-55; discussion 56-7
¹⁰ Mailey B et al. A comparison of cell-enriched fat transfer to conventional fat grafting after aesthetic procedures using a patient satisfaction survey. Ann Plast Surg. 2013 Apr;70(4):410-5
¹¹ Gentile P et al. Adipose-derived stromal vascular fraction cells and platelet rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face. J Craniofac Surg. 2014 Jan;25(1):267-72.
¹² Cervelli V et al. Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. Stem Cell Res. 2011 Mar;6(2):103-11
¹³ Rehman J et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004 Mar 16;109(10):1292-8